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#11
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"Brigitte" wrote in message ... Thank you very much for this informative post. Brigitte You're welcome. Joe |
#12
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My vet recommended using the 1% injectable ivermectin as an oral heartworm
preventative (off the record, btw) This is what he has given his dogs for years. The dosage he told me was 1 mL/100 lbs. I've heard of dosages as high as 3 mL/100 lbs, but also heard that the higher doses were causing some reproductive difficulties in breeding dogs. Ivermectin has a wide margin of safety, which is one of the reasons why a lot of horse people prefer it over moxidectin. I don't know why giving ivermectin this way would be any different from giving it as heartguard or whatever. As long as you get your dosage right, it's the same exact thing. :-) V Rondo Farms, Home of Rambo the Wonder Horse |
#13
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"Quapaw V" wrote in message ... My vet recommended using the 1% injectable ivermectin as an oral heartworm preventative (off the record, btw) This is what he has given his dogs for years. The dosage he told me was 1 mL/100 lbs. I've heard of dosages as high as 3 mL/100 lbs, but also heard that the higher doses were causing some reproductive difficulties in breeding dogs. Ivermectin has a wide margin of safety, which is one of the reasons why a lot of horse people prefer it over moxidectin. I don't know why giving ivermectin this way would be any different from giving it as heartguard or whatever. As long as you get your dosage right, it's the same exact thing. :-) V Rondo Farms, Home of Rambo the Wonder Horse The correct oral dosage of 1% Ivomec or 1% generic ivermectin for prevention of heartworms in dogs is only 0.03 mL per 110 pounds of dog. 1 mL of 1% ivermectin is enough drug to treat 33 dogs if each of them weighs 110 pounds. Please see my other post in this thread. Joe |
#14
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[quote=Dog Dude;207852]"HDTV-slingr" wrote in message
... I know the Ivermectin/heartworm thing is all over the Internet but I have a specific question that came up due to one forum resonse I found that said something to the effect of "don't give the 1% over-the-counter solution for cattle and swine to your dog or it will kill the animal" and I had to have some reassurance before doing this. I bought some generic ivermectin (not the Ivomec brand) from an online vendor and wanted to be sure before I administer a .3 cc monthly oral dose to my 3 dogs (2 standard poodles and a shepard/chow mix) to save $$$ while keeping my doggies healthy. This is the particular product I purchased, btw: http://www1.revivalanimal.com/index....2&Saved_ID=130 Last question I had, is it effective if I bury the ivermectin solution within peanut butter, cheese, bread, or something like that to mask the bad taste of the medicine, thus making it easier to sneak this stuff to the dogs? It seems it would be but ya' never know 'til ya' ask :-) TIA - The 0.3 cc (one cc equals almost exactly one mL) of 1% ivermectin you are planning to administer would be enough for an 1100 (eleven hundred) pound dog, so try to reduce the dosage. I have used breaded chicken patties, torn biscuits, broken dog biscuits, and torn hamburger buns to provide an absorbent surface for the ivermectin. My dogs have always tested heartworm-free in the seven years I have been using 1% ivermectin for cattle & swine. I have posted the info below a few times to this newsgroup. Joe __________________________________________________ _ This addresses the issue of correct monthly dosage of Ivomec (1% ivermectin) solution for PREVENTION of heartworms in dogs. It is not about the much higher dosages of ivermectin required to treat canine intestinal worms or external parasites. First, some abbreviations used in this post, posts by others, and on websites containing heartworm and ivermectin information: one gram = one thousand milligrams = 1,000 mg one gram = one million micrograms = 1,000,000 mcg = 1,000,000 ug one thousand grams = one kilogram = 1 kg = 2.20462 pounds one liter = one thousand milliters = 1000 mL one milliter = 1 mL = almost exactly 1 cc (cubic centimeter) From several websites, including ones that have Freedom Of Information copies of the original ivermectin clinical trials, the recommended dosage rate of ivermectin for PREVENTION of heartworms in dogs is 6mcg/kg. That's SIX micrograms of ivermectin per kilogram of dog. The datasheet that came with the bottle of 1% (one percent) sterile solution of Ivomec bought from a local feed store indicates that if given to CATTLE at a rate of 1mL/110lb (one milliliter of solution per one hundred ten pounds of animal), that the CATTLE would receive a dosage rate of 200mcg/kg. That's TWO HUNDRED micrograms of ivermectin per kilogram of cow, bull, calf, etc., or 33.333 times the dosage rate appropriate for dogs. Therefore, to calculate the amount of 1% (one percent) solution to give to my dogs I had to reduce the 1mL/110lb of cattle down to 0.030mL/110lb (three hundredths of one milliliter of Ivomec [1% ivermectin] solution per one hundred ten pounds) of dog. So "Lady", who weighs about 55 (fifty-five) pounds, needs 0.015mL (one and one-half hundredths of a milliliter) of 1% Ivomec solution each month. The same answer to the dosage question can be achieved another way. The Ivomec (1% ivermectin solution) label states in two places that each mL of Ivomec contains 10 mg of ivermectin. 10 mg (milligrams) equals 10,000 mcg or ug (micrograms). The correct dosage is only SIX mcg per kg (kilogram) of dog. That's six mcg per 2.20462 pounds of dog. So the 55 pound "Lady" mentioned above would need (6/10,000) X (55/2.20462) mL or 0.015 mL of the 1% variety of Ivomec each month. The pharmacy in the local Wal-Mart Supercenter sells tiny disposable applicators (like syringes without needles) that hold only one milliliter of solution, with a graduation for each hundredth of a milliliter (Update: the last batch I bought of this same brand of applicator has half as many graduations, one for each two hundredths of a milliliter). Removing one of these plastic applicators and the 1% Ivomec solution from my refrigerator (where I keep both stored), I found during the first test that 23 actual free-fall drops (as opposed to the unreliable "dps" graduation scale included on some of the aforementioned applicators) equaled 0.61mL of solution, and during the second test that 33 free-fall drops equaled 0.91mL of solution. Using the total of 56 free-fall drops being equal to 1.52mL, each one of those drops of 1% Ivomec calculated to be 0.0271428mL . Comparing this amount to the desired dosage of 0.0300000mL of 1% Ivomec solution per 110 pounds of dog (see paragraph seven, above), each one of those particular drops was therefore the correct amount to give to a dog weighing 99.5 pounds. Keep in mind that free-fall drops can be different sizes. Volume contained in each drop of 1% Ivomec is affected by temperature of the solution, temperature of the applicator, applicator material (plastic versus glass), how clean or dirty the applicator is, and the size and shape of that portion of the applicator which is close to the opening. For that reason it is a good idea to do your own tests to determine the drops per mL relationship, and to IGNORE any graduated scale (on some applicators) which claims to represent "drops" instead of hundredths or fiftieths of a mL. It is easier for me to apply a single drop of 1% Ivomec solution to an absorbent dog treat than to the back of a dog's tongue. This also keeps the applicator clean enough to store in a baggie in the refrigerator, instead of throwing it away. I refrigerate the 50mL bottle of Ivomec also. I put the drug on breaded chicken patties after they have cooled to room temperature, to avoid any possible drug breakdown due to heat. Note that a single drop of 1% Ivomec solution is almost a 2 to 1 overdose for "Lady", and more than a 2 to 1 overdose for my several 45-pound dogs. In clinical tests even Collies had to have an overdose of at least 15 to 1 before they showed any ill effects. However, it would be reasonable to assume that there are some dogs who are even more sensitive to ivermectin than any of the relative few who were in the clinical trials. A Heartgard Chewable for dogs 51 to 100 pounds delivers 272 mcg of ivermectin according to the label. One kilogram equals 2.20462 pounds. Considering the recommended dosage rate of 6 mcg per kilogram of dog, this means the Chewable is formulated for 100 pound dogs, with 51 to 99 pound dogs receiving a harmless overdose. I keep this in mind when dealing with the difficulty of precise measurement of small amounts of ivermectin solution. The dosage for a dog is 1 tenth of one cc per 10 pounds of body weight. If your dog weighs 60 lbs you give them 6 tenths of one cc. If 30 lbs then 3 tenths of one cc. I've been doing dog rescue for years and this is what we use for our rescue dogs because of the cost. You can buy a 1cc syringe at any feed and seed store or ask your vet for one. It's always been safe and we have never had any problem. We use it in treats for our tiny dogs cause it is easier to get that tiny amount in a treat. The other dogs we just shoot it in their mouth, then give them a treat to get rid of the nasty taste. Also, the heartguard is the exact same thing as Ivermectin but it has something for some kind of other worm that most adult dogs don't get anyway. The ivemectin works for other worms too. It can also be used for earmites and is used for mange. Hope this helps and makes the dosing easier to understand. Kathie_ |
#15
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Heartworm treatment can be difficult and costly for the owner of a dog so that is why prevention is the best strategy. Surgical removal of the worm is reserved for dogs in critical condition with vena cava syndrome who not candidates for treatment because of the risk of liver failure or thromboembolism.
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#16
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[quote=kathie;380656]
Quote:
Kathie, regarding what you posted above....... For PREVENTION of heartworms (not TREATMENT for existing earmites, and not TREATMENT for existing mange), the correct amount of one-percent (1%) ivermectin solution ("for cattle and swine" according to the Ivomec brand label) to give is ........... One cc if the dog weighs 3,674 pounds (not too many of them around) One tenth of a cc if the dog who weighs 367.4 pounds (still pretty rare) One hundredth of a cc for a dog who weighs 36.74 pounds One two-hundredth of a cc for a dog who weighs 18.37 pounds As you, and many others, have proven, most dogs can tolerate absurdly high overdoses of ivermectin solution without visible harm. However, some breeds of dog may begin to be harmed once a 15-to-1 overdose is exceeded. For example, if someone gives one cc of one-percent ivermectin solution to a 36.74 pound dog, the overdose is 100-to-1 . With a calculator, a Heartguard label or insert sheet, and the one-percent ivermectin label or insert sheet, you could do the same arithmetic I did to prove to yourself that the long post (rec.pets.dogs.health) of mine (Dog_Dude) back in 2005 contains accurate dosing information. Or ask a vet to show you his/her dosing handbook. Starting in 1999 I began using one-percent ivermectin solution to prevent heartworms in my nine dogs. Because of the tiny amounts of liquid involved, I would usually give my dogs at least a 4-to-1 overdose. None of them ever got heartworms despite the fact that we always had summertime mosquitos, except for the very dry summer 2010. The wildly INCORRECT dosage rate of one-tenth cc of ivermectin per 10 pounds of dog is by far the most common one found on the internet. |
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