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Adverse events diagnosed within three days of vaccine administrationin dogs
A study of more than 2,000 cats and dogs in the United Kingdom by Canine
Health Concern showed a 1 in 10 risk of adverse reactions from vaccines. This contradicts what the vaccine manufacturers report for rates of adverse reactions, which is “less than 15 adverse reactions in 100,000 animals vaccinated” (0.015 percent). Additionally, adverse reactions of small breeds are 10 times higher than large breeds, suggesting standard vaccine doses are too high for smaller animals. http://avmajournals.avma.org/doi/abs...rnalCode=javma *Objective*—To determine incidence rates and potential risk factors for vaccine-associated adverse events (VAAEs) diagnosed within 3 days of administration in dogs. *Design*—Retrospective cohort study. *Animals*—1,226,159 dogs vaccinated at 360 veterinary hospitals. *Procedure*—Electronic records from January 1, 2002, through December 31, 2003, were searched for possible VAAEs (nonspecific vaccine reaction, allergic reaction, urticaria, or anaphylaxis) diagnosed within 3 days of vaccine administration. Information included age, weight, sex, neuter status, and breed. Specific clinical signs and treatments were reviewed in a random sample of 400 affected dogs. The association between potential risk factors and a VAAE was estimated by use of multivariate logistic regression. *Results*—4,678 adverse events (38.2/10,000 dogs vaccinated) were associated with administration of 3,439,576 doses of vaccine to 1,226,159 dogs. The VAAE rate decreased significantly as body weight increased. Risk was 27% to 38% greater for neutered versus sexually intact dogs and 35% to 64% greater for dogs approximately 1 to 3 years old versus 2 to 9 months old. The risk of a VAAE significantly increased as the number of vaccine doses administered per office visit increased; each additional vaccine significantly increased risk of an adverse event by 27% in dogs ≤ 10 kg (22 lb) and 12% in dogs 10 kg. *Conclusions and Clinical Relevance*—Young adult small-breed neutered dogs that received multiple vaccines per office visit were at greatest risk of a VAAE within 72 hours after vaccination. These factors should be considered in risk assessment and risk communication with clients regarding vaccination. (/J Am Vet Med Assoc/ 2005;227:1102–1108) |
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Adverse events diagnosed within three days of vaccine administration in dogs
"Char" wrote in message m... http://avmajournals.avma.org/doi/abs...rnalCode=javma *Conclusions and Clinical Relevance*-Young adult small-breed neutered dogs that received multiple vaccines per office visit were at greatest risk of a VAAE within 72 hours after vaccination. ...........Yep, don't give multiple antigen vaccines. Period. buglady take out the dog before replying |
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Adverse events diagnosed within three days of vaccine administrationin dogs
On 3/27/2011 7:50 PM, buglady wrote:
wrote in message m... http://avmajournals.avma.org/doi/abs...rnalCode=javma *Conclusions and Clinical Relevance*-Young adult small-breed neutered dogs that received multiple vaccines per office visit were at greatest risk of a VAAE within 72 hours after vaccination. ..........Yep, don't give multiple antigen vaccines. Period. buglady take out the dog before replying And they are only considering reactions during the first three days. Autoimmune diseases can take a lot longer to show up. |
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