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Ivermectin (1%) ok for preventative heartworm treatment for dogs?
I know the Ivermectin/heartworm thing is all over the Internet but I
have a specific question that came up due to one forum resonse I found that said something to the effect of "don't give the 1% over-the-counter solution for cattle and swine to your dog or it will kill the animal" and I had to have some reassurance before doing this. I bought some generic ivermectin (not the Ivomec brand) from an online vendor and wanted to be sure before I administer a .3 cc monthly oral dose to my 3 dogs (2 standard poodles and a shepard/chow mix) to save $$$ while keeping my doggies healthy. This is the particular product I purchased, btw: http://www1.revivalanimal.com/index....2&Saved_ID=130 Last question I had, is it effective if I bury the ivermectin solution within peanut butter, cheese, bread, or something like that to mask the bad taste of the medicine, thus making it easier to sneak this stuff to the dogs? It seems it would be but ya' never know 'til ya' ask :-) TIA - |
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In article writes:
I know the Ivermectin/heartworm thing is all over the Internet but I have a specific question that came up due to one forum resonse I found that said something to the effect of "don't give the 1% over-the-counter solution for cattle and swine to your dog or it will kill the animal" and I had to have some reassurance before doing this. My vet always tests for heartworms before giving us the "all clear" signal to use Ivermectin. I guess, therefore, that Ivermectin should not be used on a dog with heartworms. http://petplace.netscape.com/article....asp?artID=842 Apparently the agent that protects is not the same agent that destroys adult heartworms. --Marshall |
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"Marshall Dermer" wrote in message ... My vet always tests for heartworms before giving us the "all clear" signal to use Ivermectin. I guess, therefore, that Ivermectin should not be used on a dog with heartworms. Apparently the agent that protects is not the same agent that destroys adult heartworms. ............ivermectin does have some effect on adult heartworms Marshall. You can give it to dogs with heartworms, but if you have a heavy microfilarial burden it can cause problems from quick die off. buglady take out the dog before replying |
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"buglady" wrote in message
nk.net... ...........ivermectin does have some effect on adult heartworms Marshall. You can give it to dogs with heartworms, but if you have a heavy microfilarial burden it can cause problems from quick die off. Yup. Went the Heartgard treatment route for Fancy because she was too malnourished for Immiticide and she was only a stage 1. 12-18 months later and she was returning negative hw tests. -- Tara |
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#6
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In article et "buglady" writes:
"Marshall Dermer" wrote in message ... My vet always tests for heartworms before giving us the "all clear" signal to use Ivermectin. I guess, therefore, that Ivermectin should not be used on a dog with heartworms. Apparently the agent that protects is not the same agent that destroys adult heartworms. ...........ivermectin does have some effect on adult heartworms Marshall. You can give it to dogs with heartworms, but if you have a heavy microfilarial burden it can cause problems from quick die off. buglady take out the dog before replying As usual thanks! --Marshall |
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"HDTV-slingr" wrote in message
... I know the Ivermectin/heartworm thing is all over the Internet but I have a specific question that came up due to one forum resonse I found that said something to the effect of "don't give the 1% over-the-counter solution for cattle and swine to your dog or it will kill the animal" and I had to have some reassurance before doing this. I bought some generic ivermectin (not the Ivomec brand) from an online vendor and wanted to be sure before I administer a .3 cc monthly oral dose to my 3 dogs (2 standard poodles and a shepard/chow mix) to save $$$ while keeping my doggies healthy. This is the particular product I purchased, btw: http://www1.revivalanimal.com/index....2&Saved_ID=130 Last question I had, is it effective if I bury the ivermectin solution within peanut butter, cheese, bread, or something like that to mask the bad taste of the medicine, thus making it easier to sneak this stuff to the dogs? It seems it would be but ya' never know 'til ya' ask :-) TIA - The 0.3 cc (one cc equals almost exactly one mL) of 1% ivermectin you are planning to administer would be enough for an 1100 (eleven hundred) pound dog, so try to reduce the dosage. I have used breaded chicken patties, torn biscuits, broken dog biscuits, and torn hamburger buns to provide an absorbent surface for the ivermectin. My dogs have always tested heartworm-free in the seven years I have been using 1% ivermectin for cattle & swine. I have posted the info below a few times to this newsgroup. Joe __________________________________________________ _ This addresses the issue of correct monthly dosage of Ivomec (1% ivermectin) solution for PREVENTION of heartworms in dogs. It is not about the much higher dosages of ivermectin required to treat canine intestinal worms or external parasites. First, some abbreviations used in this post, posts by others, and on websites containing heartworm and ivermectin information: one gram = one thousand milligrams = 1,000 mg one gram = one million micrograms = 1,000,000 mcg = 1,000,000 ug one thousand grams = one kilogram = 1 kg = 2.20462 pounds one liter = one thousand milliters = 1000 mL one milliter = 1 mL = almost exactly 1 cc (cubic centimeter) From several websites, including ones that have Freedom Of Information copies of the original ivermectin clinical trials, the recommended dosage rate of ivermectin for PREVENTION of heartworms in dogs is 6mcg/kg. That's SIX micrograms of ivermectin per kilogram of dog. The datasheet that came with the bottle of 1% (one percent) sterile solution of Ivomec bought from a local feed store indicates that if given to CATTLE at a rate of 1mL/110lb (one milliliter of solution per one hundred ten pounds of animal), that the CATTLE would receive a dosage rate of 200mcg/kg. That's TWO HUNDRED micrograms of ivermectin per kilogram of cow, bull, calf, etc., or 33.333 times the dosage rate appropriate for dogs. Therefore, to calculate the amount of 1% (one percent) solution to give to my dogs I had to reduce the 1mL/110lb of cattle down to 0.030mL/110lb (three hundredths of one milliliter of Ivomec [1% ivermectin] solution per one hundred ten pounds) of dog. So "Lady", who weighs about 55 (fifty-five) pounds, needs 0.015mL (one and one-half hundredths of a milliliter) of 1% Ivomec solution each month. The same answer to the dosage question can be achieved another way. The Ivomec (1% ivermectin solution) label states in two places that each mL of Ivomec contains 10 mg of ivermectin. 10 mg (milligrams) equals 10,000 mcg or ug (micrograms). The correct dosage is only SIX mcg per kg (kilogram) of dog. That's six mcg per 2.20462 pounds of dog. So the 55 pound "Lady" mentioned above would need (6/10,000) X (55/2.20462) mL or 0.015 mL of the 1% variety of Ivomec each month. The pharmacy in the local Wal-Mart Supercenter sells tiny disposable applicators (like syringes without needles) that hold only one milliliter of solution, with a graduation for each hundredth of a milliliter (Update: the last batch I bought of this same brand of applicator has half as many graduations, one for each two hundredths of a milliliter). Removing one of these plastic applicators and the 1% Ivomec solution from my refrigerator (where I keep both stored), I found during the first test that 23 actual free-fall drops (as opposed to the unreliable "dps" graduation scale included on some of the aforementioned applicators) equaled 0.61mL of solution, and during the second test that 33 free-fall drops equaled 0.91mL of solution. Using the total of 56 free-fall drops being equal to 1.52mL, each one of those drops of 1% Ivomec calculated to be 0.0271428mL . Comparing this amount to the desired dosage of 0.0300000mL of 1% Ivomec solution per 110 pounds of dog (see paragraph seven, above), each one of those particular drops was therefore the correct amount to give to a dog weighing 99.5 pounds. Keep in mind that free-fall drops can be different sizes. Volume contained in each drop of 1% Ivomec is affected by temperature of the solution, temperature of the applicator, applicator material (plastic versus glass), how clean or dirty the applicator is, and the size and shape of that portion of the applicator which is close to the opening. For that reason it is a good idea to do your own tests to determine the drops per mL relationship, and to IGNORE any graduated scale (on some applicators) which claims to represent "drops" instead of hundredths or fiftieths of a mL. It is easier for me to apply a single drop of 1% Ivomec solution to an absorbent dog treat than to the back of a dog's tongue. This also keeps the applicator clean enough to store in a baggie in the refrigerator, instead of throwing it away. I refrigerate the 50mL bottle of Ivomec also. I put the drug on breaded chicken patties after they have cooled to room temperature, to avoid any possible drug breakdown due to heat. Note that a single drop of 1% Ivomec solution is almost a 2 to 1 overdose for "Lady", and more than a 2 to 1 overdose for my several 45-pound dogs. In clinical tests even Collies had to have an overdose of at least 15 to 1 before they showed any ill effects. However, it would be reasonable to assume that there are some dogs who are even more sensitive to ivermectin than any of the relative few who were in the clinical trials. A Heartgard Chewable for dogs 51 to 100 pounds delivers 272 mcg of ivermectin according to the label. One kilogram equals 2.20462 pounds. Considering the recommended dosage rate of 6 mcg per kilogram of dog, this means the Chewable is formulated for 100 pound dogs, with 51 to 99 pound dogs receiving a harmless overdose. I keep this in mind when dealing with the difficulty of precise measurement of small amounts of ivermectin solution. ________________________________________________ |
#8
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On Mon, 10 Jan 2005 06:09:11 GMT, "Dog Dude"
wrote: I bought some generic ivermectin (not the Ivomec brand) from an online vendor and wanted to be sure before I administer a .3 cc monthly oral dose to my 3 dogs (2 standard poodles and a shepard/chow mix) to save $$$ while keeping my doggies healthy. This is the particular product I purchased, btw: http://www1.revivalanimal.com/index....2&Saved_ID=130 Last question I had, is it effective if I bury the ivermectin solution within peanut butter, cheese, bread, or something like that to mask the bad taste of the medicine, thus making it easier to sneak this stuff to the dogs? It seems it would be but ya' never know 'til ya' ask :-) TIA - The 0.3 cc (one cc equals almost exactly one mL) of 1% ivermectin you are planning to administer would be enough for an 1100 (eleven hundred) pound dog, so try to reduce the dosage. I have used breaded chicken patties, torn biscuits, broken dog biscuits, and torn hamburger buns to provide an absorbent surface for the ivermectin. My dogs have always tested heartworm-free in the seven years I have been using 1% ivermectin for cattle & swine. Thanks, Joe! I didn't realize this would be an OD. Judging from Internet postings, many people are indeed OD'ing their doggies on that 1% ivermectin stuff. |
#9
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Thanks, Joe! I didn't realize this would be an OD. Judging from Internet postings, many people are indeed OD'ing their doggies on that 1% ivermectin stuff. You're welcome. I forgot to mention a few things. The safe (when dosed within reason) product from Merial Limited is labeled "Ivomec (ivermectin) injection for Cattle and Swine--1% Sterile Solution". It is their product number 41380, as labeled on the outside of the box. Merial also makes another product called Ivomec PLUS, which contains extra drugs that will KILL dogs, I have been told. You bought generic 1% ivermectin. I do not know if it comes with/without the extra drugs that are in the dangerous Ivomec PLUS product. You could compare the drugs in the ordinary Ivomec product (41380) with those contained in the Ivomec PLUS product to determine which ones to avoid when buying a generic substitute for Ivomec. Joe |
#10
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"Dog Dude" wrote in message ... "HDTV-slingr" wrote in message ... I know the Ivermectin/heartworm thing is all over the Internet but I have a specific question that came up due to one forum resonse I found that said something to the effect of "don't give the 1% over-the-counter solution for cattle and swine to your dog or it will kill the animal" and I had to have some reassurance before doing this. I bought some generic ivermectin (not the Ivomec brand) from an online vendor and wanted to be sure before I administer a .3 cc monthly oral dose to my 3 dogs (2 standard poodles and a shepard/chow mix) to save $$$ while keeping my doggies healthy. This is the particular product I purchased, btw: http://www1.revivalanimal.com/index....2&Saved_ID=130 Last question I had, is it effective if I bury the ivermectin solution within peanut butter, cheese, bread, or something like that to mask the bad taste of the medicine, thus making it easier to sneak this stuff to the dogs? It seems it would be but ya' never know 'til ya' ask :-) TIA - The 0.3 cc (one cc equals almost exactly one mL) of 1% ivermectin you are planning to administer would be enough for an 1100 (eleven hundred) pound dog, so try to reduce the dosage. I have used breaded chicken patties, torn biscuits, broken dog biscuits, and torn hamburger buns to provide an absorbent surface for the ivermectin. My dogs have always tested heartworm-free in the seven years I have been using 1% ivermectin for cattle & swine. I have posted the info below a few times to this newsgroup. Joe __________________________________________________ _ This addresses the issue of correct monthly dosage of Ivomec (1% ivermectin) solution for PREVENTION of heartworms in dogs. It is not about the much higher dosages of ivermectin required to treat canine intestinal worms or external parasites. First, some abbreviations used in this post, posts by others, and on websites containing heartworm and ivermectin information: one gram = one thousand milligrams = 1,000 mg one gram = one million micrograms = 1,000,000 mcg = 1,000,000 ug one thousand grams = one kilogram = 1 kg = 2.20462 pounds one liter = one thousand milliters = 1000 mL one milliter = 1 mL = almost exactly 1 cc (cubic centimeter) From several websites, including ones that have Freedom Of Information copies of the original ivermectin clinical trials, the recommended dosage rate of ivermectin for PREVENTION of heartworms in dogs is 6mcg/kg. That's SIX micrograms of ivermectin per kilogram of dog. The datasheet that came with the bottle of 1% (one percent) sterile solution of Ivomec bought from a local feed store indicates that if given to CATTLE at a rate of 1mL/110lb (one milliliter of solution per one hundred ten pounds of animal), that the CATTLE would receive a dosage rate of 200mcg/kg. That's TWO HUNDRED micrograms of ivermectin per kilogram of cow, bull, calf, etc., or 33.333 times the dosage rate appropriate for dogs. Therefore, to calculate the amount of 1% (one percent) solution to give to my dogs I had to reduce the 1mL/110lb of cattle down to 0.030mL/110lb (three hundredths of one milliliter of Ivomec [1% ivermectin] solution per one hundred ten pounds) of dog. So "Lady", who weighs about 55 (fifty-five) pounds, needs 0.015mL (one and one-half hundredths of a milliliter) of 1% Ivomec solution each month. The same answer to the dosage question can be achieved another way. The Ivomec (1% ivermectin solution) label states in two places that each mL of Ivomec contains 10 mg of ivermectin. 10 mg (milligrams) equals 10,000 mcg or ug (micrograms). The correct dosage is only SIX mcg per kg (kilogram) of dog. That's six mcg per 2.20462 pounds of dog. So the 55 pound "Lady" mentioned above would need (6/10,000) X (55/2.20462) mL or 0.015 mL of the 1% variety of Ivomec each month. The pharmacy in the local Wal-Mart Supercenter sells tiny disposable applicators (like syringes without needles) that hold only one milliliter of solution, with a graduation for each hundredth of a milliliter (Update: the last batch I bought of this same brand of applicator has half as many graduations, one for each two hundredths of a milliliter). Removing one of these plastic applicators and the 1% Ivomec solution from my refrigerator (where I keep both stored), I found during the first test that 23 actual free-fall drops (as opposed to the unreliable "dps" graduation scale included on some of the aforementioned applicators) equaled 0.61mL of solution, and during the second test that 33 free-fall drops equaled 0.91mL of solution. Using the total of 56 free-fall drops being equal to 1.52mL, each one of those drops of 1% Ivomec calculated to be 0.0271428mL . Comparing this amount to the desired dosage of 0.0300000mL of 1% Ivomec solution per 110 pounds of dog (see paragraph seven, above), each one of those particular drops was therefore the correct amount to give to a dog weighing 99.5 pounds. Keep in mind that free-fall drops can be different sizes. Volume contained in each drop of 1% Ivomec is affected by temperature of the solution, temperature of the applicator, applicator material (plastic versus glass), how clean or dirty the applicator is, and the size and shape of that portion of the applicator which is close to the opening. For that reason it is a good idea to do your own tests to determine the drops per mL relationship, and to IGNORE any graduated scale (on some applicators) which claims to represent "drops" instead of hundredths or fiftieths of a mL. It is easier for me to apply a single drop of 1% Ivomec solution to an absorbent dog treat than to the back of a dog's tongue. This also keeps the applicator clean enough to store in a baggie in the refrigerator, instead of throwing it away. I refrigerate the 50mL bottle of Ivomec also. I put the drug on breaded chicken patties after they have cooled to room temperature, to avoid any possible drug breakdown due to heat. Note that a single drop of 1% Ivomec solution is almost a 2 to 1 overdose for "Lady", and more than a 2 to 1 overdose for my several 45-pound dogs. In clinical tests even Collies had to have an overdose of at least 15 to 1 before they showed any ill effects. However, it would be reasonable to assume that there are some dogs who are even more sensitive to ivermectin than any of the relative few who were in the clinical trials. A Heartgard Chewable for dogs 51 to 100 pounds delivers 272 mcg of ivermectin according to the label. One kilogram equals 2.20462 pounds. Considering the recommended dosage rate of 6 mcg per kilogram of dog, this means the Chewable is formulated for 100 pound dogs, with 51 to 99 pound dogs receiving a harmless overdose. I keep this in mind when dealing with the difficulty of precise measurement of small amounts of ivermectin solution. ________________________________________________ Thank you very much for this informative post. Brigitte |
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