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Adverse events diagnosed within three days of vaccine administrationin dogs



 
 
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  #1  
Old March 27th 11, 09:05 PM posted to rec.pets.dogs.health
Char
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Posts: 771
Default Adverse events diagnosed within three days of vaccine administrationin dogs

A study of more than 2,000 cats and dogs in the United Kingdom by Canine
Health Concern showed a 1 in 10 risk of adverse reactions from vaccines.
This contradicts what the vaccine manufacturers report for rates of
adverse reactions, which is “less than 15 adverse reactions in 100,000
animals vaccinated” (0.015 percent). Additionally, adverse reactions of
small breeds are 10 times higher than large breeds, suggesting standard
vaccine doses are too high for smaller animals.

http://avmajournals.avma.org/doi/abs...rnalCode=javma

*Objective*—To determine incidence rates and potential risk factors for
vaccine-associated adverse events (VAAEs) diagnosed within 3 days of
administration in dogs.

*Design*—Retrospective cohort study.

*Animals*—1,226,159 dogs vaccinated at 360 veterinary hospitals.

*Procedure*—Electronic records from January 1, 2002, through December
31, 2003, were searched for possible VAAEs (nonspecific vaccine
reaction, allergic reaction, urticaria, or anaphylaxis) diagnosed within
3 days of vaccine administration. Information included age, weight, sex,
neuter status, and breed. Specific clinical signs and treatments were
reviewed in a random sample of 400 affected dogs. The association
between potential risk factors and a VAAE was estimated by use of
multivariate logistic regression.

*Results*—4,678 adverse events (38.2/10,000 dogs vaccinated) were
associated with administration of 3,439,576 doses of vaccine to
1,226,159 dogs. The VAAE rate decreased significantly as body weight
increased. Risk was 27% to 38% greater for neutered versus sexually
intact dogs and 35% to 64% greater for dogs approximately 1 to 3 years
old versus 2 to 9 months old. The risk of a VAAE significantly increased
as the number of vaccine doses administered per office visit increased;
each additional vaccine significantly increased risk of an adverse event
by 27% in dogs ≤ 10 kg (22 lb) and 12% in dogs 10 kg.

*Conclusions and Clinical Relevance*—Young adult small-breed neutered
dogs that received multiple vaccines per office visit were at greatest
risk of a VAAE within 72 hours after vaccination. These factors should
be considered in risk assessment and risk communication with clients
regarding vaccination. (/J Am Vet Med Assoc/ 2005;227:1102–1108)



  #2  
Old March 28th 11, 12:50 AM posted to rec.pets.dogs.health
buglady
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Posts: 863
Default Adverse events diagnosed within three days of vaccine administration in dogs


"Char" wrote in message
m...
http://avmajournals.avma.org/doi/abs...rnalCode=javma
*Conclusions and Clinical Relevance*-Young adult small-breed neutered
dogs that received multiple vaccines per office visit were at greatest
risk of a VAAE within 72 hours after vaccination.

...........Yep, don't give multiple antigen vaccines. Period.

buglady
take out the dog before replying


  #3  
Old March 28th 11, 01:18 AM posted to rec.pets.dogs.health
Char
external usenet poster
 
Posts: 771
Default Adverse events diagnosed within three days of vaccine administrationin dogs

On 3/27/2011 7:50 PM, buglady wrote:
wrote in message
m...
http://avmajournals.avma.org/doi/abs...rnalCode=javma
*Conclusions and Clinical Relevance*-Young adult small-breed neutered
dogs that received multiple vaccines per office visit were at greatest
risk of a VAAE within 72 hours after vaccination.

..........Yep, don't give multiple antigen vaccines. Period.

buglady
take out the dog before replying


And they are only considering reactions during the first three days.
Autoimmune diseases can take a lot longer to show up.
 




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